Levels of Oxidative Stress Marker Malondialdehyde and Some Lipid Fractions in Women Diagnosed with Pre-Eclampsia in a Rural Hospital in South East Nigeria
Published: 2021-12-21
Page: 285-292
Issue: 2021 - Volume 4 [Issue 1]
Nnamdi J. J. Chinonso *
Department of Chemical Pathology, Faculty of Basic Clinical Science, Nnamdi Azikiwe University Awka, Nnewi Campus, Anambara State, Nigeria.
Amah U. Kalu
Department of Chemical Pathology, Faculty of Basic Clinical Science, Nnamdi Azikiwe University Awka, Nnewi Campus, Anambara State, Nigeria.
Myke-Mbata K. Blessing
Department of Chemical Pathology, Benue State University, Nigeria.
Anikwe C. Christian
Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.
Okeke C. Stellamaris
Department of Medical Laboratory Science, Faculty of Health Science and Technology, Nnamdi Azikiwe University, Nnewi Campus, Anambara State, Nigeria.
Ahams E. Chika
Department of Chemical Pathology, Faculty of Basic Clinical Science, Nnamdi Azikiwe University Awka, Nnewi Campus, Anambara State, Nigeria.
Iwuagwu G. Obioma
Department of Accident and Emergency, Federal Medical Center Owerri, Nigeria.
Oti D. Chukwudi
Department of Medical Laboratory Science, Abia State University Uturu, Nigeria.
Ogbonnaya V. Ifunanya
Department of Medical Laboratory Science, Faculty of Health Science and Technology, Nnamdi Azikiwe University, Nnewi Campus, Anambara State, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
Background: In this modern era, the incidence in the prevalence of pre-eclampsia keep increasing globally and Nigeria in particular, even in the face of extensive researches there are still un-collaborating results on the association between lipid peroxidation product (malondialdehyde) and the disease of imprecise etiology (pre-eclampsia). The disturbance in the metabolism of antioxidants and excess lipid peroxidation because of stress and other co-factors during pregnancy may be a contributing factor in the development of preeclampsia.
Aim: This investigation was carried out to compare the serum MDA status and some lipid fractions in women with preeclampsia and normal pregnancy in a rural hospital of Imo State Nigeria.
Methods: A cross sectional study was carried out on 50 pre-eclampsia and 50 normotensive pregnant women attending the Department of Medicine and Antenatal clinic of specialist Hospital Umuguma, Owerri Imo State. The ethics committee and participants gave their consent, (HMB/IM/VOL.30/110/2019/007) after the study protocol was detailed to them and approved.
Results: The mean serum MDA TG, VLDL-C, LDL were significantly higher in pre-eclamptic patients when compared to the controls (P<0.05). The mean HDL-C was lower in pre-eclamptic subjects when compared with the control (P<0.05). There was no significant difference in the level of the mean Total Cholesterols between the groups (P>0.05).
Conclusion: This current investigation showed significant increase in lipid per oxidation activities and alteration in lipid metabolism in pregnant women with pre-eclampsia and which may be due to the failure of compensatory antioxidant functions in pregnant women with this disorder.
Keywords: Pre-eclampsia, lipid peroxidation, malondialdehyde.